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The effect of twin-to-twin delivery time intervals on neonatal outcome for second twins.

Journal article
Authors Linnéa Lindroos
Anders Elfvin
Lars Ladfors
Ulla-Britt Wennerholm
Published in BMC pregnancy and childbirth
Volume 18
Issue 1
Pages 36
ISSN 1471-2393
Publication year 2018
Published at Institute of Clinical Sciences, Department of Pediatrics
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 36
Language en
Subject categories Pediatrics


The objective was to examine the effect of twin-to-twin delivery intervals on neonatal outcome for second twins.This was a retrospective, hospital-based study, performed at a university teaching hospital in Western Sweden. Twin deliveries between 2008 and 2014 at ≥32 + 0 weeks of gestation, where the first twin was delivered vaginally, were included. Primary outcome was a composite outcome of metabolic acidosis, Apgar < 4 at 5 min or peri/neonatal mortality in the second twin. Secondary outcome was a composite outcome of neonatal morbidity.A total of 527 twin deliveries were included. The median twin-to-twin delivery interval time was 19 min (range 2-399 min) and 68% of all second twins were delivered within 30 min. Primary outcome occurred in 2.6% of the second twins. Median twin-to-twin delivery interval was 34 min (8-78 min) for the second twin with a primary outcome, and 19 min (2-399 min) for the second twin with no primary outcome (p = 0.028). Second twins delivered within a twin-to-twin interval of 0-30 min had a higher pH in umbilical artery blood gas than those delivered after 30 min (pH 7.23 and pH 7.20, p <  0.0001). Secondary outcome was not associated with twin-to-twin delivery interval time. The combined vaginal-cesarean delivery rate was 6.6% (n = 35) and the rate was higher with twin-to-twin delivery interval >  30 min (p <  0.0001).An association, but not necessarily a causality, between twin-to-twin delivery interval and primary outcome was seen. An upper time limit on twin-to-twin delivery time intervals may be justified. However, the optimal time interval needs further studies.

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