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Gammahydroxybutyric acid: central biochemical and behavioral effects in neonatal rats.

Journal article
Authors Thomas Hedner
Jan A Hedner
Knut Iversen
Per Wessberg
Per Lundborg
Published in Pharmacology, biochemistry, and behavior
Volume 23
Issue 2
Pages 185-9
ISSN 0091-3057
Publication year 1985
Published at Department of Pharmacology
Pages 185-9
Language en
Keywords Animals, Animals, Newborn, physiology, Biogenic Amines, metabolism, Brain, metabolism, Female, Heart Rate, drug effects, Hydroxybutyrates, pharmacology, Motor Activity, drug effects, Pregnancy, Rats, Rats, Inbred Strains, Respiration, drug effects, Sodium Oxybate, metabolism, pharmacology, Synaptic Transmission, drug effects, Time Factors
Subject categories Pharmacology


Administration of gammahydroxybutyric acid (GHBA) to 4 days old animals caused a dose dependent decrease in locomotor activity. GHBA also induced a marked hypoventilation, irregular breathing and finally apnea, while heart rate was slightly increased. Changes in monoamine neurotransmitter turnover indicated an inhibition of dopamine (DA) neurotransmission. It is concluded that GHBA mechanisms in the neonatal rat brain are biochemically as well as functionally mature at an early age and that the effects on locomotor activity and respiratory regulation at least partly may involve interactions with central DA neurotransmission.

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