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Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage

Journal article
Authors M. Sykora
J. Putaala
A. Meretoja
Turgut Tatlisumak
D. Strbian
Published in Acta Neurologica Scandinavica
Volume 137
Issue 1
Pages 105-108
ISSN 0001-6314
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 105-108
Language en
Links doi.org/10.1111/ane.12817
Keywords beta-blockers, intracerebral hemorrhage, mortality, outcome, acute ischemic-stroke, heart-rate, subarachnoid hemorrhage, impact, admission, cohort, risk
Subject categories Neurosciences

Abstract

BackgroundBeta-blocker therapy has been suggested to have neuroprotective properties in the setting of acute stroke; however, the evidence is weak and contradictory. We aimed to examine the effects of pre-admission therapy with beta-blockers (BB) on the mortality following spontaneous intracerebral hemorrhage (ICH). ResultsA total of 1013 patients with ICH were included in the analysis. Patients taking BB were significantly older, had a higher premorbid mRS score, had more DNR orders, and more comorbidities as atrial fibrillation, hypertension, diabetes mellitus, ischemic heart disease, and heart failure. After adjustment for age, pre-existing comorbidities, and prior use of antithrombotic and antihypertensive medications, no differences in in-hospital mortality (OR 1.1, 95% CI 0.8-1.7), 12-month mortality (OR 1.3, 95% CI 0.9-1.9), and 3-month mortality (OR 1.2, 95% CI 0.8-1.7) emerged. ConclusionPre-admission use of BB was not associated with mortality after ICH.

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