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Role of Bile Acids in Metabolic Control.

Journal article
Authors Antonio Molinaro
Annika Wahlström
Hanns-Ulrich Marschall
Published in Trends in endocrinology and metabolism: TEM
Volume 29
Issue 1
Pages 31-41
ISSN 1879-3061
Publication year 2018
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 31-41
Language en
Links dx.doi.org/10.1016/j.tem.2017.11.00...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Gastroenterology and Hepatology

Abstract

Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble nutrients regulate numerous metabolic processes, including glucose, lipid, and energy homeostasis. The signaling actions of bile acids are mediated through specific bile-acid-activated nuclear and membrane-bound receptors. These receptors are not only expressed by tissues within the enterohepatic circulation such as the liver and the intestine, but also in other organs where bile acids mediate their systemic actions. In this review, we discuss bile acid signaling and the interplay with the gut microbiota in the pathophysiology of obesity, type 2 diabetes, and non-alcoholic fatty liver disease, and the role of surgical and pharmacological interventions on bile acid profiles and metabolism.

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