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Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.

Review article
Authors Markus J. Tamás
Bruno Fauvet
Philipp Christen
Pierre Goloubinoff
Published in Current genetics
Volume 64
Issue 1
Pages 177–181
ISSN 1432-0983
Publication year 2018
Published at Department of Chemistry and Molecular Biology
Pages 177–181
Language en
Links dx.doi.org/10.1007/s00294-017-0748-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Microbiology, Cell Biology, Molecular biology, Toxicology, Cell and molecular biology, Biochemistry, Biochemistry and Molecular Biology

Abstract

Cadmium is a highly poisonous metal and a human carcinogen, but the molecular mechanisms underlying its cellular toxicity are not fully understood. Recent findings in yeast cells indicate that cadmium exerts its deleterious effects by inducing widespread misfolding and aggregation of nascent proteins. Here, we discuss this novel mode of toxic heavy metal action and propose a mechanism by which molecular chaperones may reduce the damaging effects of heavy metal ions on protein structures.

Page Manager: Webmaster|Last update: 9/11/2012
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