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When epigenetics meets bioengineering-A material characteristics and surface topography perspective

Review article
Authors Lena Larsson
Sophia P. Pilipchuk
William V. Giannobile
Rogerio M. Castilho
Published in Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume 106
Issue 5
Pages 2065-2071
ISSN 1552-4973
Publication year 2017
Published at Institute of Odontology, Section 2
Pages 2065-2071
Language en
Links https://doi.org/10.1002/jbm.b.33953
Keywords Epigenetics, Material energy, Regenerative medicine, Surface topography, Tissue engineering, Titanium
Subject categories Dentistry

Abstract

© 2017 Wiley Periodicals, Inc. The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology.

Page Manager: Webmaster|Last update: 9/11/2012
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