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Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial.

Journal article
Authors Olivier Carcuac
Jan Derks
Ingemar Abrahamsson
Jan Wennström
Max Petzold
Tord Berglundh
Published in Journal of clinical periodontology
Volume 44
Issue 12
Pages 1294-1303
ISSN 1600-051X
Publication year 2017
Published at Institute of Odontology
Department of Economics, Statistical Research Unit
Pages 1294-1303
Language en
Keywords dental implant, implant surface characteristics, surgical treatment
Subject categories Periodontology


This study reports on the 3-year follow-up of patients enrolled in a randomized controlled clinical trial on surgical treatment of advanced peri-implantitis.A total of 100 patients with advanced peri-implantitis were randomly assigned to one of four treatment groups. Surgical therapy aiming at pocket elimination was performed and, in three test groups, supplemented by either systemic antibiotics, use of an antiseptic agent for implant surface decontamination or both. Outcomes were evaluated after 1 and 3 years by means of clinical and radiological examinations. Differences between groups were explored by regression analysis.Clinical examinations at 3 years after treatment revealed (i) improved peri-implant soft tissue health with a mean reduction in probing depth of 2.7 mm and a reduction in bleeding/suppuration on probing of 40% and (ii) stable peri-implant marginal bone levels (mean bone loss during follow-up: 0.04 mm). Implant surface characteristics had a significant impact on 3-year outcomes, in favour of implants with non-modified surfaces. Benefits of systemic antibiotics were limited to implants with modified surfaces and to the first year of follow-up.It is suggested that surgical treatment of peri-implantitis is effective and that outcomes of therapy are affected by implant surface characteristics. Potential benefits of systemic antibiotics are not sustained over 3 years.

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