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A longitudinal study on subjective sleep disturbance and risk of dementia in 85-year-olds followed over 15 years.

Authors Johan Skoog
Valgeir Thorvaldsson
Ingmar Skoog
Boo Johansson
Published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Vol. 13, Issue 7, P1043
ISSN 1552-5260
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Department of Psychology
Centre for Ageing and Health (Agecap)
Language en
Subject categories Gerontology, specializing in Medical and Health Sciences, Psychology, Geriatrics


Recent research indicates that sleep may play a role in the development of dementia. However, few studies have been conducted in the oldest-old ages. The aim of this study was to examinethe association between subjective sleep disturbance and incidentdementia in a population-based sample of 85-year-olds without dementia at baseline, followed until their death. Methods:Arepresen-tative sample of 85-year-olds (N¼494, 144 men, 350 women) were examined with comprehensive neuropsychiatric examinations. 147 individuals were excluded due to dementia at baseline, two subjects lacked data on subjective sleep disturbance, leaving 345 individuals. Sleep disturbance was assessed with a question regarding a subjective experience of decreased sleep during the last month while dementia during follow-up was diagnosed by geriatric psychiatrists according to DSM-III-R. Results: Subjective sleep disturbance at baseline wasnot related to incident dementia during follow-up (hazard ratio, 1.10; 95% CI, 0.77-1.59). Conclusions: We found in populations-based sample of 85-year-olds that subjective sleep disturbance was not related to incident dementia during follow-up. Future research need to elucidate whether sleep disturbance affect older individuals differently in younger compared to older ages.

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