To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Creating Optical Activity… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Creating Optical Activity: Total Spontaneous Resolution and Viedma Ripening

Doctoral thesis
Authors Per Martin Björemark
Date of public defense 2017-11-10
ISBN 978-91-629-0327-5
Publisher Göteborgs universitet
Place of publication Göteborg
Publication year 2017
Published at Department of Chemistry and Molecular Biology
Language en
Links hdl.handle.net/2077/53817
Keywords Optical activity, absolute asymmetric synthesis, total spontaneous resolution, Viedma ripening, grinding, chirality, conglomerate, coordination compound, coordination polymer, single crystal X-ray diffraction, solvent free oxidation, nantioselective sulfide oxidation, solid state VCD
Subject categories Chemical Sciences

Abstract

The creation of optical activity has been considered as something impossible even though reports of such creation via total spontaneous resolution since the 1940´s have been published. More recently Viedma ripening have been developed that also produce enantiopure bulk product. Both methods are examples of absolute asymmetric synthesis i.e. the synthesis of optically active product from non-optically active starting materials, catalysts or auxiliaries. In this work twenty-four new compounds have been synthesized, isolated and characterized with X-ray diffraction. Out of these have eleven been found to crystallize as conglomerates as chiral enantiopure crystals which are optically active. The discovered conglomerates have been analyzed with solid state techniques as circular dichroism (CD) and vibrational circular dichroism(VCD). For the moderately labile [Ru(PS)2Cl2], [Ru(dmso)2(NS)Cl2 and [Ru(dmso)2(SS)Cl2] have the chirality been fixated by oxidizing the ligand in solution to the corresponding sulfoxide. For the highly labile [Co(bpy)3](PF6)2 the chirality has been fixated by oxidizing the metal from cobalt(II), solvent free in the solid state, to the inert cobalt (III) with bromine vapor or solid iodine. The optical activity of the inert complexes has been analyzed with solution techniques such as CD, HPLC and ORD. The optical activity of the complexes [Mo(CO)4PS] and [W(CO)4PS] have been analyzed with solid state VCD with less than tenth of a milligram sample and high-quality spectra have been obtained in 20 minutes. Total spontaneous resolution has been achieved with the compounds [Ru(PS)2Cl2], [Ru(dmso)2(NS)Cl2, [Ru(dmso)2(SS)Cl2] and [Ag(PS)2](BF4) in good yield and high ee. Viedma ripening has been demonstrated for the complexes [Ag(PS)2](BF4), [Mo(CO)4PS], [W(CO)4PS] and [Cu(mtp)2(NO3)2]. Viedma ripening has been found to be viable for the production of large quantities of optically pure metal complex.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?