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Extracts of Equisetum giganteum L and Copaifera reticulate Ducke show strong antiviral activity against the sexually transmitted pathogen herpes simplex virus type 2

Journal article
Authors Marianela Patzi Churqui
Liza Lind
Karolina Thörn
Alexandra Svensson
O. Savolainen
K. T. Aranda
Kristina Eriksson
Published in Journal of Ethnopharmacology
Volume 210
Pages 192-197
ISSN 0378-8741
Publication year 2018
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 192-197
Language en
Links doi.org/10.1016/j.jep.2017.08.010
Keywords Antiviral, Copaifera reticulate Ducke, Equisetum giganteum L, Genital, HSV-2
Subject categories Rheumatology and Autoimmunity

Abstract

Ethnopharmacological relevance Equisetum giganteum L and Copaifera reticulate Ducke have been traditionally used by women of the Tacana tribe in the Bolivian Amazonas for genital hygiene and for treatment of genital infection/inflammation. Aim of the study To assess the ability of extracts from Equisetum giganteum L and Copaifera reticulate Ducke to block genital viral infection by herpes simplex virus type 2. Materials and Methods Equisetum giganteum L and Copaifera reticulate Ducke were collected from the Amazon region of La Paz, Bolivia. Extracts were prepared and screened for anti-viral activity against herpes simplex virus type 2 (HSV-2) using both in vitro and in in vivo models of infection. Results Equisetum giganteum L and Copaifera reticulate Ducke efficiently blocked HSV-2 infection of cell cultures without major cell cytotoxic effects. Extracts of Equisetum giganteum L and Copaifera reticulate Ducke could prevent HSV-2 disease development when administered together with virus in a mouse model of genital HSV-2 infection. In vitro analyses revealed that both plant extracts exerted their anti-HSV-2 effects by interfering with viral cell attachment and entry, but could not block viral replication post entry. Conclusions These studies show that extracts of Equisetum giganteum L and Copaifera reticulate Ducke have potent antiviral activities against HSV-2 comparable to those two previously identified plants, Croton lechleri Müll. Arg. and Uncaria tomentosa (Willd. ex Schult.) DC. These studies confirm that plants used by the Tacana tribe could be explored further for the development of novel topical antiviral microbicides. © 2017 Elsevier Ireland Ltd

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