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Evaluation of the correlations between the absorbed bone marrow dose and bone marrow response during the first cycle of 177Lu-DOTATATE treatment

Conference contribution
Authors Linn Hagmarker
Johanna Svensson
Tobias Magnander
Bo Wängberg
Peter Bernhardt
Published in European Association of Nuclear Medicine
Publication year 2017
Published at Institute of Clinical Sciences, Department of Radiation Physics
Institute of Clinical Sciences, Department of Surgery
Institute of Clinical Sciences, Department of Oncology
Language en
Subject categories Radiation biology, Cancer and Oncology


The bone marrow is one of the organs at risk during 177Lu-DOTATATE treatments. To monitor the bone marrow function, the levels of hemoglobin, white blood cells and platelet counts serves as a substitute for bone marrow response. The aim of this study is to evaluate different ways to measure hematological reponse and investigate if its possible to acchieve a dose response relationship already after the first treatment cycle, this using an image-based two-compartment method. Significant correlations were found after the first treatment cycle between the absorbed bone marrow dose and the response of platelet counts using nadir, the response rate and a trinomial function.

Page Manager: Webmaster|Last update: 9/11/2012

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