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The regulation of gut mucosal IgA B-cell responses: recent developments

Journal article
Authors Nils Y Lycke
Mats Bemark
Published in Mucosal Immunology
Volume 10
Issue 6
Pages 1361-1374
ISSN 1933-0219
Publication year 2017
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 1361-1374
Language en
Links doi.org/10.1038/mi.2017.62
Keywords class switch recombination, segmented filamentous bacteria, helper, t-cells, cd103(+) dendritic cells, immunoglobulin-a generation, germinal, center formation, cholera antitoxin memory, cytidine deaminase aid, april-deficient mice, intestinal m cells, Immunology, neal mm, 1995, virology, v211, p474
Subject categories Immunology in the medical area

Abstract

The majority of activated B cells differentiate into IgA plasma cells, with the gut being the largest producer of immunoglobulin in the body. Secretory IgA antibodies have numerous critical functions of which protection against infections and the role for establishing a healthy microbiota appear most important. Expanding our knowledge of the regulation of IgA B-cell responses and how effective mucosal vaccines can be designed are of critical importance. Here we discuss recent developments in the field that shed light on the uniqueness and complexity of mucosal IgA responses and the control of protective IgA responses in the gut, specifically.

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