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Minor adaptations of ethanol-induced release of taurine following chronic ethanol intake in the rat

Conference paper
Authors Mia Ericson
Lisa Ulenius
Louise Adermark
Bo Söderpalm
Published in Advances in Experimental Medicine and Biology
ISSN 0065-2598
Publisher Springer
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Language en
Links doi.org/10.1007/978-94-024-1079-2_1...
Keywords Alcohol, Dopamine, In vivo Microdialysis, Self Administration
Subject categories Neurology

Abstract

Alcohol dependence is a puzzling brain disorder causing enormous suffering and financial costs world-wide. One of the few common denominators of all addictive drugs is activation of the mesolimbic dopamine system resulting in increased dopamine levels in the nucleus accumbens. In order to understand the development of addiction and find new efficient treatment strategies we need to understand how addictive drugs increase dopamine following acute and chronic administration of drugs. In the search for mechanisms underlying ethanol’s ability to increase dopamine in the nucleus accumbens we have found taurine to be of major importance, although the complete picture remains to be disclosed. The aim of the present study was to explore whether chronic voluntary ethanol intake influences the ethanol-induced elevation of taurine. By means of in vivo micro-dialysis we found that voluntary intake of large amounts of ethanol for 12 weeks only had a modest influence on ethanol-induced elevations of taurine in the rat. © 2017, Springer Science+Business Media B.V.

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