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Mapping quantitative trait loci in yeast

Journal article
Authors G. Liti
Jonas Warringer
Anders Blomberg
Published in Cold Spring Harbor Protocols
Volume 2017
Issue 8
Pages 631-635
ISSN 1940-3402
Publication year 2017
Published at Department of Chemistry and Molecular Biology
Pages 631-635
Language en
Links doi.org/10.1101/pdb.prot089060
Keywords fungal cell culture, gene function, genetic variability, metabolite, nonhuman, phenotype, publication, quantitative trait locus, Saccharomyces
Subject categories Chemical Sciences, Molecular biology

Abstract

Natural Saccharomyces strains isolated from the wild differ quantitatively in molecular and organismal phenotypes. Quantitative trait loci (QTL) mapping is a powerful approach for identifying sequence variants that alter gene function. In yeast, QTL mapping has been used in designed crosses to map functional polymorphisms. This approach, outlined here, is often the first step in understanding the molecular basis of quantitative traits. New large-scale sequencing surveys have the potential to directly associate genotypes with organismal phenotypes, providing a broader catalog of causative genetic variants. Additional analysis of intermediate phenotypes (e.g., RNA, protein, or metabolite levels) can produce a multilayered and integrated view of individual variation, producing a high-resolution view of the genotype–phenotype map. © 2017 Cold Spring Harbor Laboratory Press.

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