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Health-related quality of life and emotional well-being after epilepsy surgery: A prospective, controlled, long-term follow-up

Journal article
Authors Anna Edelvik
Charles Taft
Gerd Ekstedt
Kristina Malmgren
Published in Epilepsia
Volume 58
Issue 10
Pages 1706-1715
ISSN 0013-9580
Publication year 2017
Published at University of Gothenburg Centre for person-centred care (GPCC)
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Institute of Health and Care Sciences
Pages 1706-1715
Language en
Links doi.org/10.1111/epi.13874
Keywords Quality of life, Patient satisfaction, Mood, Epilepsy surgery, Long-term, temporal-lobe epilepsy, employment outcomes, controlled-trial, seizures, lobectomy, cognition, anxiety, sweden, sf-36, mood, Neurosciences & Neurology
Subject categories Neurosciences

Abstract

ObjectiveTo evaluate health-related quality of life (HRQOL) and emotional well-being in resective epilepsy surgery and nonoperated patients at long-term follow-up. MethodsThis is a prospective cohort study where patients undergoing presurgical work-up during 1995-1998 completed the Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression scale (HAD) at baseline, and 2 and 14years after resective surgery or presurgical evaluation (nonoperated patients). SF-36 scores were compared to a normative population. Proportions of patients reaching HRQOL changes of minimum clinically important difference (MCID) were calculated. ResultsAt 14-year follow-up, operated patients scored equal to or better than the normative sample on all SF-36 domains except Social Functioning and Mental Health. Physical component summary (PCS) was better and mental component summary (MCS) was worse than for the normative sample. Nonoperated patients scored worse than the normative sample on five of eight domains, and on PCS and MCS. Change in seizure status from 2 to 14years did not affect PCS or MCS means. Improvement reaching MCID from baseline to long-term was seen in 50% (PCS) and 47% (MCS) of operated and in 33% (PCS) and 38% (MCS) of nonoperated patients. Worsening was seen in 18% (PCS) and 22% (MCS) of operated and in 38% (PCS) and 38% (MCS) of nonoperated patients. Differences between groups were nonsignificant. HAD scores did not differ between groups, and the numbers of possible or probable cases were low. Patient satisfaction with surgery was higher in operated seizure-free patients. Only 5% of all operated patients considered surgery not to be overall beneficial. SignificanceAt the group level, HRQOL was stable 14years after surgery compared to after 2years. Social Functioning and Mental Health were still below, but other domains were similar to the normative sample. Individual patterns did not follow seizure outcome changes, indicating that multiple factors are important for long-term HRQOL.

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