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The history behind successful uterine transplantation in humans

Journal article
Authors L. A. R. Castellón
M. I. G. Amador
R. E. D. González
M. S. J. Eduardo
C. Díaz-García
Niclas Kvarnström
Mats Brännström
Published in Jornal Brasileiro de Reproducao Assistida
Volume 21
Issue 2
Pages 126-134
ISSN 1517-5693
Publication year 2017
Published at Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 126-134
Language en
Links doi.org/10.5935/1518-0557.20170028
Keywords Infertility, Transplantation, Uterus
Subject categories Obstetrics, Gynecology and Reproductive Medicine

Abstract

This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immunosuppression, rejection diagnosis, peculiarities of pregnancy in immunosuppressed patients, and patients with special uterine conditions. In animal species, the first live birth from UTx was achieved in a syngeneic mouse model in 2003. Twenty-five UTx procedures have been performed in humans. The first two cases were unsuccessful, but established the need for rigorous research to improve success rates. As a result of a controlled clinical study under a strictly designed research protocol, nine subsequent UTx procedures have resulted in six healthy live births, the first of them in 2014. Further failed UTx procedures have been performed in China, Czech Republic, Brazil, Germany, and the United States, most of which using living donors. Albeit still an experimental procedure in, UTx is the first potential alternative for the treatment of absolute uterine factor infertility (AUFI). © 2017, Sociedade Brasileira de Reproducao Assistida. All rights reserved.

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