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Variation in Staphylococcus aureus Colonization in Relation to Disease Severity in Adults with Atopic Dermatitis during a Five-month Follow-up

Journal article
Authors M. Alsterholm
L. Strombeck
Annika Ljung
Nahid Karami
Johan Widjestam
M. Gillstedt
Christina Åhrén
J. Faergemann
Published in Acta Dermato-Venereologica
Volume 97
Issue 7
Pages 802-807
ISSN 0001-5555
Publication year 2017
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 802-807
Language en
Links dx.doi.org/10.2340/00015555-2667
Keywords atopic dermatitis, S. aureus, SCORAD, PFGE, FIELD GEL-ELECTROPHORESIS, METHICILLIN-RESISTANT, UVB RADIATION, BLEACH, BATHS, SCORAD INDEX, TASK-FORCE, SKIN, ECZEMA, EXOTOXINS, CONSENSUS, Dermatology
Subject categories Dermatology and Venereal Diseases

Abstract

The aim of this study was to monitor Staphylococcus aureus colonization and disease severity in adults with atopic dermatitis (AD) during 5 months. Twenty-one patients attended 3 visits each for severity SCORing of Atopic Dermatitis (SCORAD) assessment, quantitative cultures from the skin and conventional cultures from the anterior nares, tonsils and perineum. S. aureus isolates were typed for strain identity with pulsed-field gel electrophoresis (PFGE). Seventy-one percent of patients were colonized with S. aureus on lesional skin at least once. Density (colony-forming units (CFU)/cm(2)) was higher on lesional skin than on non-lesional skin (p < 0.05). Density on lesional skin and number of colonized body sites were positively correlated with SCORAD (p = 0.0003 and p = 0.007, respectively). Persistent carriers of the same strain on lesional skin had higher mean SCORAD index than intermittent/noncarriers (36.3 and 17.1, respectively, p = 0.002). The results show a temporal correlation between several aspects of S. aureus colonization and disease severity in AD raising the question of the importance of this in pathogenesis and treatment.

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