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Evidence that Osteocytes in Autogenous Bone Fragments can Repair Disrupted Canalicular Networks and Connect with Osteocytes in de novo Formed Bone on the Fragment Surface

Journal article
Authors Furqan A. Shah
Anders Palmquist
Published in Calcified Tissue International
Volume 101
Issue 3
Pages 321-327
ISSN 0171-967X
Publication year 2017
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 321-327
Language en
Links dx.doi.org/10.1007/s00223-017-0283-...
Keywords Autogenous bone, Early implant healing, Osteocyte, Scanning electron microscopy, dental implants, growth-factors, basic science, substitutes, graft, Endocrinology & Metabolism
Subject categories Biomaterials Science

Abstract

Autogenous bone fragments generated during surgery (e.g. implant site preparation) accelerate bone formation by the release of a large variety of growth factors from the extracellular matrix and the cells contained within. Osteocytes, whether viable or apoptotic, within such fragments are able to recruit osteoclasts to a site of bone remodelling. Here, using correlative scanning electron microscopy, we provide compelling evidence that at one week healing in the Sprague Dawley rat tibia, following surgery (and/or the placement of a bone-anchored implant), autogenous bone fragments support bone formation on their surface. Furthermore, osteocytes within the autogenous fragments are frequently able to repair the disrupted canalicular networks and appear to connect with osteocytes (or osteoblastic-osteocytes) in the de novo formed bone on the surface of the fragment.

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