Till startsida
To content Read more about how we use cookies on gu.se

Study on montmorillonite/insulin/TiO2 hybrid nanocomposite as a new oral drug-delivery system

Journal article
Authors Y. Kamari
Payam Ghiaci
M. Ghiaci
Published in Materials Science and Engineering C
Volume 75
Pages 822-828
ISSN 0928-4931
Publication year 2017
Published at Department of Chemistry and Molecular Biology
Pages 822-828
Language en
Links dx.doi.org/10.1016/j.msec.2017.02.1...
Keywords Hybrid nanocomposite, Insulin, Intercalation, Montmorillonite, Oral drug delivery, TiO2, Clay minerals, Coatings, Deionized water, Titanium dioxide, Drug entrapment, Hybrid nanocomposites, Montmorillonite nanocomposites, Oral drug delivery system, Porous coatings, Titanium butoxide, Zeta potential analysis, Nanocomposites
Subject categories Pharmacology, Pharmaceutical Sciences


This study was conducted in two main stages. In the first stage, drug-loaded montmorillonite nanocomposites were prepared by intercalation of insulin into the montmorillonite layers in acidic deionized (DI) water. In the second stage, to increase the release of insulin from the prepared nanocomposites they were coated with TiO2, an inorganic porous coating, by using titanium (IV) butoxide, as precursor. The prepared nanocomposites were characterized by FT-IR, XRD, FE-SEM, BET, DLS and Zeta potential analysis. After investigating the release behaviour of the nanocomposites by UV–Vis absorbance technique, the results revealed that incorporation of porous TiO2 coating increased the drug entrapment noticeably, and decreased the amount of drug release, so that nanocomposites without and with TiO2 coating released the drug after 60 min and 22 h in pH 7.4, respectively. These results could be used in converting the insulin utilization from injection to oral. © 2017 Elsevier B.V.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?