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An ex vivo model using human peritoneum to explore mesh-tissue integration.

Journal article
Authors Peter Falk
Fernando Ruiz-Jasbon
Karin Strigård
Ulf Gunnarsson
Marie-Lois Ivarsson
Published in Biology open
Volume 6
Issue 9
Pages 1391-1395
ISSN 2046-6390
Publication year 2017
Published at Institute of Clinical Sciences, Department of Surgery
Pages 1391-1395
Language en
Links dx.doi.org/10.1242/bio.024992
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Biocompatibility, Experimental model, Mesh, Peritoneal tissue, Peritoneum, Synthetic mesh
Subject categories Gastroenterology and Hepatology, Surgery

Abstract

Biological compatibility, in terms of implantation of foreign mesh material in hernia surgery, still needs experimental investigation. Present study develops an experimental model using human peritoneum to study the integration between tissue and different mesh material. The ex vivo model using peritoneal tissue was studied with different mesh material, and integration was monitored over time using microscopy.It could be demonstrated that the peritoneal model may be kept viable in culture for several weeks. Cell migration was seen after 7-10 days in culture and could be further monitored over several weeks. The use of a human artificial model environment enabling the investigation of tissue/mesh integration has, to our knowledge, not been described previously.This proof-of-concept model was developed, for the investigation of peritoneal biology and the integration between tissue and different mesh material. It has the potential to be useful in studies on other important biological mechanisms involving the peritoneum.

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