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Hepatitis B surface antigen on subviral particles reduces the neutralizing effect of anti-HBs antibodies on hepatitis B viral particles in vitro

Journal article
Authors Gustaf E Rydell
Kasthuri Prakash
Helene Norder
Magnus Lindh
Published in Virology
Volume 509
Pages 67-70
ISSN 0042-6822
Publication year 2017
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 67-70
Language en
Links https://doi.org/10.1016/j.virol.201...
Keywords HBV, Neutralisation, Dane particles, Attachment, HBsAg, virus infection, binding, polypeptide, receptor, dna, Virology
Subject categories Infectious Medicine, Virology

Abstract

During hepatitis B virus (HBV) infections subviral particles (SVP) consisting mainly of hepatitis B surface antigen are present at much higher concentration than viral particles (VP) in serum. To investigate reasons for this excess of SVP production, SVP and VP were fractionated on a Nycodenz gradient and analyzed for HBV infection of HepG2-NTCP cells with and without anti-HBs antibodies. Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SW had little effect on viral entry, supporting the assumption that SW serve as decoy facilitating cell-to-cell spread of HBV in the presence of neutralizing antibodies.

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