To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Hepatitis B surface antig… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Hepatitis B surface antigen on subviral particles reduces the neutralizing effect of anti-HBs antibodies on hepatitis B viral particles in vitro

Journal article
Authors Gustaf E Rydell
Kasthuri Prakash
Helene Norder
Magnus Lindh
Published in Virology
Volume 509
Pages 67-70
ISSN 0042-6822
Publication year 2017
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 67-70
Language en
Keywords HBV, Neutralisation, Dane particles, Attachment, HBsAg, virus infection, binding, polypeptide, receptor, dna, Virology
Subject categories Infectious Medicine, Virology


During hepatitis B virus (HBV) infections subviral particles (SVP) consisting mainly of hepatitis B surface antigen are present at much higher concentration than viral particles (VP) in serum. To investigate reasons for this excess of SVP production, SVP and VP were fractionated on a Nycodenz gradient and analyzed for HBV infection of HepG2-NTCP cells with and without anti-HBs antibodies. Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SW had little effect on viral entry, supporting the assumption that SW serve as decoy facilitating cell-to-cell spread of HBV in the presence of neutralizing antibodies.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?