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The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.

Journal article
Authors Maike Wolters
Carmen Dering
Alfonso Siani
Paola Russo
Jaakko Kaprio
Patrizia Risé
Luis A Moreno
Stefaan De Henauw
Kirsten Mehlig
Toomas Veidebaum
Denés Molnár
Michael Tornaritis
Licia Iacoviello
Yannis Pitsiladis
Claudio Galli
Ronja Foraita
Claudia Börnhorst
Published in PloS one
Volume 12
Issue 7
Pages e0181485
ISSN 1932-6203
Publication year 2017
Published at Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit
Pages e0181485
Language en
Subject categories Epidemiology


The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP.A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to <10 years from six European countries was included. The association between rs174546 (T

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