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(18)F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease.

Journal article
Authors Niklas Mattsson
Michael Schöll
Olof Strandberg
Ruben Smith
Sebastian Palmqvist
Philip S Insel
Douglas Hägerström
Tomas Ohlsson
Henrik Zetterberg
Jonas Jögi
Kaj Blennow
Oskar Hansson
Published in EMBO molecular medicine
Volume 9
Issue 9
Pages 1212-1223
ISSN 1757-4684
Publication year 2017
Published at Institute of Neuroscience and Physiology
Pages 1212-1223
Language en
Links dx.doi.org/10.15252/emmm.201707809
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Radiology, Nuclear Medicine and Medical Imaging, Clinical Laboratory Medicine, Neurology

Abstract

To elucidate the relationship between cerebrospinal fluid (CSF) total-tau (T-tau) and phosphorylated tau (P-tau) with the tau PET ligand (18)F-AV-1451 in Alzheimer's disease (AD), we examined 30 cognitively healthy elderly (15 with preclinical AD), 14 prodromal AD, and 39 AD dementia patients. CSF T-tau and P-tau were highly correlated (R = 0.92, P < 0.001), but they were only moderately associated with retention of (18)F-AV-1451, and mainly in demented AD patients. (18)F-AV-1451, but not CSF T-tau or P-tau, was strongly associated with atrophy and cognitive impairment. CSF tau was increased in preclinical AD, despite normal (18)F-AV-1451 retention. However, not all dementia AD patients exhibited increased CSF tau, even though (18)F-AV-1451 retention was always increased at this disease stage. We conclude that CSF T-tau and P-tau mainly behave as biomarkers of "disease state", since they appear to be increased in many cases of AD at all disease stages, already before the emergence of tau aggregates. In contrast, (18)F-AV-1451 is a biomarker of "disease stage", since it is increased in clinical stages of the disease, and is associated with brain atrophy and cognitive decline.

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