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Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes

Journal article
Authors E. Chorell
Ulrika Andersson Hall
Carolina Gustavsson
K. Berntorp
J. Puhkala
R. Luoto
T. Olsson
Agneta Holmäng
Published in Metabolism-Clinical and Experimental
Volume 72
Pages 27-36
ISSN 0026-0495
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 27-36
Language en
Keywords Gestational diabetes mellitus, Type 2 diabetes mellitus, Metabolomics, Multivariate statistics, Branched-chain amino acids, chain amino-acids, insulin-resistance, intermediate metabolism, fatty-acids, mellitus, glucose, sensitivity, secretion, association, prediction, Endocrinology & Metabolism
Subject categories Neurology


Context. Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective. To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design. The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 +/- 0.6) and postpartum (10.5 +/- 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. Results. Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. Conclusions. Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy. (C) 2017 Elsevier Inc. All rights reserved.

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