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The meiosis specific modification of mammalian telomeres

Review article
Authors Hiroki Shibuya
Yoshinori Watanabe
Published in Cell Cycle
Volume 13
Pages 2024-2028
ISSN 1538-4101
Publication year 2014
Published at
Pages 2024-2028
Language en
Keywords Chromosome, Cohesin, Meiosis, Nuclear envelope, Telomere
Subject categories Cell Biology

Abstract

During meiosis, rapid chromosome movements within the nucleus enable homologous chromosomes to acquire physical juxtaposition. In most organisms, chromosome ends, telomeres, tethered to the transmembrane LINC-complex mediate this movement by transmitting cytoskeletal forces to the chromosomes. While the majority of molecular studies have been performed using lower eukaryotes as model systems, recent studies have identified mammalian meiotic telomere regulators, including the LINC-complex SUN1/KASH5 and the meiosis-specific telomere binding protein TERB1. This review highlights the molecular regulations of mammalian meiotic telomeres in comparison with other model systems and discusses some future perspectives. © 2014 Landes Bioscience.

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