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Neural control of blood pressure in women: differences according to age

Journal article
Authors A. B. Peinado
R. E. Harvey
E. C. Hart
N. Charkoudian
T. B. Curry
W. T. Nicholson
Gunnar B Wallin
M. J. Joyner
J. N. Barnes
Published in Clinical Autonomic Research
Volume 27
Issue 3
Pages 157-165
ISSN 0959-9851
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 157-165
Language en
Links dx.doi.org/10.1007/s10286-017-0403-...
Keywords Aging, Baroreflex function, Menopause, Sympathetic nerve activity, SYMPATHETIC-NERVE ACTIVITY, LONG-TERM CONTROL, ARTERIAL-PRESSURE, BAROREFLEX SENSITIVITY, AUTONOMIC SUPPORT, HUMANS, 17-BETA-ESTRADIOL, MODULATION, ESTROGEN, BALANCE
Subject categories Neurosciences

Abstract

Purpose The blood pressure "error signal'' represents the difference between an individual's mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the "T50''). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause. Methods We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25 +/- 1 years) and 12 postmenopausal women (61 +/- 2 years) before and during complete autonomic blockade with trimethaphan camsylate. Results At baseline, young women had a negative error signal (-8 +/- 1 versus 2 +/- 1 mmHg, p < 0.001; respectively) and lower muscle sympathetic nerve activity (15 +/- 1 versus 33 +/- 3 bursts/min, p < 0.001; respectively) than older women. The change in diastolic blood pressure after autonomic blockade was associated with baseline T50 in older women (r = -0.725, p = 0.008) but not in young women (r = -0.337, p = 0.29). Women with the most negative error signal had the lowest muscle sympathetic nerve activity in both groups (young: r = 0.886, p < 0.001; older: r = 0.870, p < 0.001). Conclusions Our results suggest that there are differences in baroreflex control of muscle sympathetic nerve activity between young and older women, using the T50 and error signal analysis. This approach provides further information on autonomic control of blood pressure in women.

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