To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Genome-wide physical acti… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Journal article
Authors M. Graff
R. A. Scott
A. E. Justice
K. L. Young
M. F. Feitosa
L. Barata
T. W. Winkler
A. Y. Chu
A. Mahajan
D. Hadley
L. T. Xue
T. Workalemahu
N. L. Heard-Costa
M. den Hoed
T. S. Ahluwalia
Q. B. Qi
J. S. Ngwa
F. Renstrom
L. Quaye
J. D. Eicher
J. E. Hayes
M. Cornelis
Z. Kutalik
E. Lim
J. Luan
J. E. Huffman
W. H. Zhang
W. Zhao
P. J. Griffin
T. Haller
S. Ahmad
P. M. Marques-Vidal
S. Bien
L. Yengo
A. Teumer
A. V. Smith
M. Kumari
M. N. Harder
J. M. Justesen
M. E. Kleber
M. Hollensted
K. Lohman
N. V. Rivera
J. B. Whitfield
J. H. Zhao
H. M. Stringham
L. P. Lyytikainen
C. Huppertz
G. Willemsen
W. J. Peyrot
Y. Wu
K. Kristiansson
A. Demirkan
M. Fornage
M. Hassinen
L. F. Bielak
G. Cadby
T. Tanaka
R. Magl
P. J. Van der Most
A. U. Jackson
J. L. Bragg-Gresham
V. Vitart
J. Marten
P. Navarro
C. Bellis
D. Pasko
A. Johansson
S. Snitker
Y. C. Cheng
Joel Eriksson
U. Lim
M. Aadahl
L. S. Adair
N. Amin
B. Balkau
J. Auvinen
J. Beilby
R. N. Bergman
S. Bergmann
A. G. Bertoni
J. Blangero
A. Bonnefond
L. L. Bonnycastle
J. B. Borja
S. Brage
F. Busonero
S. Buyske
H. Campbell
P. S. Chines
F. S. Collins
T. Corre
G. D. Smith
G. E. Delgado
N. Dueker
M. Dorr
T. Ebeling
G. Eiriksdottir
T. Esko
J. D. Faul
M. Fu
K. Faerch
C. Gieger
S. Glaser
J. Gong
P. Gordon-Larsen
H. Grallert
T. B. Grammer
N. Grarup
G. van Grootheest
K. Harald
N. D. Hastie
A. S. Havulinna
D. Hernandez
L. Hindorff
L. J. Hocking
O. L. Holmens
C. Holzapfel
J. J. Hottenga
J. Huang
T. Huang
J. Hui
C. Huth
N. Hutri-Kahonen
A. L. James
John-Olov Jansson
M. A. Jhun
M. Juonala
L. Kinnunen
H. A. Koistinen
I. Kolcic
P. Komulainen
J. Kuusisto
K. Kvaloy
M. Kahonen
T. A. Lakka
L. J. Launer
B. Lehne
C. M. Lindgren
Mattias Lorentzon
R. Luben
M. Marre
Y. Milaneschi
K. L. Monda
G. W. Montgomery
M. H. M. De Moor
A. Mulas
M. Muller-Nurasyid
A. W. Musk
R. Mannikko
S. Mannisto
N. Narisu
M. Nauck
J. A. Nettleton
I. M. Nolte
A. J. Oldehinkel
M. Olden
K. K. Ong
S. Padmanabhan
L. Paternoster
J. Perez
M. Perola
A. Peters
U. Peters
P. A. Peyser
I. Prokopenko
H. Puolijoki
O. T. Raitakari
T. Rankinen
L. J. Rasmussen-Torvik
R. Rawal
P. M. Ridker
L. M. Rose
I. Rudan
C. Sarti
M. A. Sarzynski
K. Savonen
W. R. Scott
S. Sanna
A. R. Shuldiner
S. Sidney
G. Silbernagel
B. H. Smith
J. A. Smith
H. Snieder
A. Stancakova
B. Sternfeld
A. J. Swift
T. Tammelin
S. T. Tan
B. Thorand
D. Thuillier
Liesbeth Vandenput
H. Vestergaard
J. V. van Vliet-Ostaptchouk
M. C. Vohl
U. Volker
G. Waeber
M. Walker
S. Wild
A. Wong
A. F. Wright
M. C. Zillikens
N. Zubair
C. A. Haiman
L. Lemarchand
U. Gyllensten
Claes Ohlsson
C. Ohlsson
A. Hofman
F. Rivadeneira
A. G. Uitterlinden
L. Perusse
J. F. Wilson
C. Hayward
O. Polasek
F. Cucca
K. Hveem
C. A. Hartman
A. Tonjes
S. Bandinelli
L. J. Palmer
S. L. R. Kardia
R. Rauramaa
T. I. A. Sorensen
J. Tuomilehto
V. Salomaa
Bwjh Penninx
E. J. C. de Geus
D. I. Boomsma
T. Lehtimaki
M. Mangino
M. Laakso
C. Bouchard
N. G. Martin
D. Kuh
Y. M. Liu
A. Linneberg
W. Marz
K. Strauch
M. Kivimaki
T. B. Harris
V. Gudnason
H. Volzke
L. Qi
M. R. Jarvelin
J. C. Chambers
J. S. Kooner
P. Froguel
C. Kooperberg
P. Vollenweider
G. Hallmans
T. Hansen
O. Pedersen
A. Metspalu
N. J. Wareham
C. Langenberg
D. R. Weir
D. J. Porteous
E. Boerwinkle
D. I. Chasman
G. R. Abecasis
I. Barroso
M. I. McCarthy
T. M. Frayling
J. R. O'Connell
C. M. van Duijn
M. Boehnke
I. M. Heid
K. L. Mohlke
D. P. Strachan
C. S. Fox
C. T. Liu
J. N. Hirschhorn
R. J. Klein
A. D. Johnson
I. B. Borecki
P. W. Franks
K. E. North
L. A. Cupples
R. J. F. Loos
T. O. Kilpelainen
Charge Consortium; EPIC-InterAct Consortium; PAGE Consortium Charge Consortium; EPIC-InterAct Consortium; PAGE Consortium
Published in PLoS Genet
Volume 13
Issue 4
ISSN 1553-7404
Publication year 2017
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Centre for Bone and Arthritis Research
Institute of Neuroscience and Physiology
Language en
Links doi.org/10.1371/journal.pgen.100652...
Keywords body-mass index, reactive protein-levels, gene-expression, identical-twins, adipocyte differentiation, association metaanalysis, activity questionnaires, fat distribution, binding protein, food-intake, Genetics & Heredity
Subject categories Clinical Medicine

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?