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Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?

Journal article
Authors B. R. Chrcanovic
J. Kisch
Tomas Albrektsson
A. Wennerberg
Published in International Journal of Oral and Maxillofacial Surgery
Volume 46
Issue 6
Pages 782-788
ISSN 0901-5027
Publication year 2017
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 782-788
Language en
Links 10.1016/j.ijom.2017.01.016
Keywords dental implant, implant failure, selective serotonin reuptake inhibitors, multivariate generalized, bone-mineral density, systemic factors, superficial characteristics, abutment connection, oral implants, periodontitis, metaanalysis, transporter, impact, antidepressants
Subject categories Dentistry, Surgical research


The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931(35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for nonusers (P = 0.007). Kaplan-Meier analysis showed a statistically significant difference in the cumulative survival rate (P < 0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P = 0.530), nor did the multilevel model (P = 0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.

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