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Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index.

Journal article
Authors Stephanie J B Vos
Martin P J van Boxtel
Olga J G Schiepers
Kay Deckers
Marjolein de Vugt
Isabelle Carrière
Jean-François Dartigues
Karine Peres
Sylvaine Artero
Karen Ritchie
Lucia Galluzzo
Emanuele Scafato
Giovanni B Frisoni
Martijn Huisman
Hannie C Comijs
Simona F Sacuiu
Ingmar Skoog
Kate Irving
Catherine A O'Donnell
Frans R J Verhey
Pieter Jelle Visser
Sebastian Köhler
Published in Journal of Alzheimer's disease : JAD
Volume 58
Issue 2
Pages 537-547
ISSN 1875-8908
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Centre for Ageing and Health (Agecap)
Pages 537-547
Language en
Subject categories Other Medical Sciences


Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia.We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old.9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual's LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1-16).In midlife (55-69 y, n = 3,256) and late life (70-79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80-97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia.LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.

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