To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Lack of Fc Gamma Receptor… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and Adjuvants

Journal article
Authors Jia-Bin Sun
Jan Holmgren
Xianghua Zhou
Published in Scandinavian Journal of Immunology
Volume 85
Issue 4
Pages 264-271
ISSN 0300-9475
Publication year 2017
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 264-271
Language en
Links 10.1111/sji.12528
Keywords regulatory t-cells, monoclonal-antibodies, induced arthritis, deficient, mice, igg receptors, mast-cells, riii, disease, inflammation, apoptosis
Subject categories Microbiology in the medical area, Immunology in the medical area


The Fcc receptor IIIA (Fc gamma RIIIA) has traditionally been known as a positive regulator of immune responses. Consistent with this, mice deficient in Fc gamma RIIIA are protected from various inflammation-associated pathologies including several autoimmune diseases. In contrast to this accepted dogma, we show here that mice lacking Fc gamma RIIIA developed increased rather than reduced both humoral and cellular immune responses to mucosal (sublingual) immunization with ovalbumin (OVA) given together with the strong mucosal adjuvant cholera toxin as well as to parenteral (subcutaneous) immunization with OVA in complete Freund's adjuvant. After either route of immunization, in comparison with concomitantly immunized wild-type mice, Fc gamma RIIIA(-/)-mice had increased serum anti-OVA IgG (IgG1 but not IgG2) antibody responses as well as augmented cellular responses that included memory B cells and effector T cells. The increments in immune responses in Fc gamma RIIIA(-/)-mice were similar to those seen in Fc gamma RIIIA(-/)-mice. Furthermore, OVA-pulsed Fc gamma RIIIA(-/)-DCs, similar to OVA-specific Fc gamma RIIIA(-/-), had enhanced capacity to activate OVA-specific OT-II T cells, which was even further pronounced when DCs were pulsed with IgG1-complexed OVA. Our data support an inhibitory-regulatory role of Fc gamma RIIIA on vaccine/ adjuvant-induced immune responses and demonstrate that lack of Fc gamma RIIIA can promote rather than suppress both humoral and cellular immune responses.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?