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Long-Term Results Following Antibiotic Treatment of Acute Appendicitis in Adults.

Journal article
Authors Kent Lundholm
Jeanette Hansson-Assarsson
Cecilia Engström
Britt-Marie Iresjö
Published in World journal of surgery
Volume 41
Issue 9
Pages 2245-2250
ISSN 1432-2323
Publication year 2017
Published at Institute of Clinical Sciences, Department of Surgery
Pages 2245-2250
Language en
Links dx.doi.org/10.1007/s00268-017-3987-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Clinical Medicine, Surgery, Gastroenterology and Hepatology

Abstract

Antibiotic treatment of acute appendicitis has gained interest and inquiries. Reports have demonstrated both safety and high resolution of symptoms and inflammation following antibiotic treatment of appendicitis, but information on long-term results is required. Our present aim was therefore to evaluate long-term recurrence rate of initial antibiotics-alone treatment for suspected acute appendicitis.Patients with favourable response to antibiotics in earlier randomized (RCT, n = 97) and population-based (PBT, n = 342) studies as well as subsequently treated non-randomized (Non-R, n = 271) patients are evaluated for long-term risk to relapse demanding surgical appendectomy; altogether 710 patients.Clinical characteristics among randomized and non-randomized patients were similar without any statistical difference according to abdominal symptoms and degree of systemic inflammation (CRP, WCC) when antibiotic treatment started. Females and males showed the same results. The median follow-up time was 2162 days (5.92 years), and the range across highest and lowest follow-up was 3495 days (range 2-3497) for the entire group, without significant differences among subgroups (RCT, PBT, Non-R). The cumulative probability for relapse of appendicitis demanding appendectomy was: 0.09, 0.12, 0.12 and 0.13 at 1-, 2-, 3- and 5-year follow-up, with a probability of 0.86 ± 0.013 without appendectomy after 8 years. This may imply an overall benefit of 60-70% by antibiotics during expected 10-year follow-up accounting for initial treatment failures at 10-23% in our published reports.Antibiotic treatment is safe and effective as a first-line therapy in unselected adults with acute appendicitis with a risk around 15% for long-term relapse following favourable initial treatment response.

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