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Does Pretreatment Tumor Growth Hold Prognostic Information for Patients with Glioblastoma?

Journal article
Authors Anne Line Stensjøen
Erik Magnus Berntsen
Vilde E Mikkelsen
Sverre H Torp
Asgeir Store Jakola
Øyvind Salvesen
Ole Solheim
Published in World neurosurgery
Volume 101
Pages 686–694.e4
ISSN 1878-8769
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 686–694.e4
Language en
Links dx.doi.org/10.1016/j.wneu.2017.03.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Radiology, Nuclear Medicine and Medical Imaging, Neurology, Cancer and Oncology

Abstract

Glioblastomas are highly aggressive and heterogeneous tumors, both in terms of patient outcome and molecular profile. Magnetic resonance imaging of tumor growth could potentially reveal new insights about tumor biology noninvasively. The aim of this exploratory retrospective study was to investigate the prognostic potential of pretreatment growth rate of glioblastomas, after controlling for known prognostic factors.A growth model derived from clinical pretreatment postcontrast T1-weighted magnetic resonance imaging images was used to divide 106 glioblastoma patients into 2 groups. The "faster growth" group had tumors growing faster than expected based on their volume at diagnosis, whereas the "slower growth" group had tumors growing slower than expected. Associations between tumor growth and survival were examined by the use of multivariable Cox regression and logistic regression.None of the known prognostic factors were significantly associated with tumor growth. An extended multivariable Cox model showed that during the first 12 months of follow-up, there was no significant difference in survival between faster and slower growing tumors. Beyond 12 months' follow-up, however, there was a significant, independent survival benefit in having a tumor with slower pretreatment growth. In a multiple logistic regression model including patients receiving both radiotherapy and chemotherapy (n = 82), slower pre-treatment growth of the tumor was shown to be a significant predictor of 2-year survival (odds ratio 4.4).Pretreatment glioblastoma growth harbors prognostic information. Patients with slower growing tumors have higher odds of survival beyond 2 years, adjusted for other prognostic factors.

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