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The Upsides and Downsides of Organelle Interconnectivity

Journal article
Authors D. E. Gottschling
Thomas Nyström
Published in Cell
Volume 169
Issue 1
ISSN 0092-8674
Publication year 2017
Published at Institute of Biomedicine
Language en
Keywords mitochondrial quality-control, membrane contact sites, saccharomyces-cerevisiae, asymmetric inheritance, endoplasmic-reticulum, damaged proteins, budding yeast, life-span, interaction networks, aggregated proteins, Biochemistry & Molecular Biology, Cell Biology
Subject categories Cell biology, Biochemistry and Molecular Biology


Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in interorganelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub- system proteostasis and complex adaptive systems theory.

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