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Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.

Journal article
Authors Rodrigo R Marcondes
Manuel Maliqueo
Romina Fornes
Anna Benrick
Min Hu
Niklas Ivarsson
Mattias Carlström
Samuel W Cushman
Karin G Stenkula
Gustavo A R Maciel
Elisabet Stener-Victorin
Published in Molecular and cellular endocrinology
Volume 448
Pages 66–76
ISSN 1872-8057
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 66–76
Language en
Subject categories Basic Medicine


Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch pathway genes, and restored altered mesenteric adipocytes morphology. In conclusion, exercise restored mesenteric adipocytes morphology in DHT- and LET-exposed mice, and insulin sensitivity and mesenteric expression of lipolysis-related genes in LET-exposed mice. Benefits could be explained by downregulation of Notch, and modulation of browning and lipolysis pathways in the adipose tissue.

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