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Allergic disease in 8-year old children is preceded by delayed B-cell maturation.

Journal article
Authors Anna Strömbeck
Inger Nordström
Kerstin Andersson
Helen Andersson
Susanne Johansen
Cristina Maglio
Hardis Rabe
Ingegerd Adlerberth
Agnes E Wold
Bill Hesselmar
Anna Rudin
Anna-Carin Lundell
Published in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume 47
Issue 7
Pages 918-928
ISSN 1365-2222
Publication year 2017
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Clinical Sciences, Department of Pediatrics
Institute of Biomedicine, Department of Infectious Medicine
Pages 918-928
Language en
Subject categories Pediatrics


We previously reported that exposure to a farming environment is allergy-protective, while high proportions of neonatal immature/naïve CD5(+) B cells and putative regulatory T cells (Tregs) are risk factors for development of allergic disease and sensitization up to 3 years of age.To examine if B- and T-cell maturation are associated with allergic disease and farming environment over the first 8 years in life.In the prospective FARMFLORA study, including both farming and non-farming families, 48 out of 65 children took part in the 8-year follow-up study. Various B- and T-cell maturation variables were examined in blood samples obtained at several occasions from birth to 8 years of age and related to doctors' diagnosed allergic disease and sensitization, and to farming environment.We found that the incidence of allergic disease was lower among farmers' compared to non-farmers' children during the 8-years follow-up period, and that farmers' children had higher proportions of memory B cells at 8 years of age. Moreover, a high proportion of neonatal CD5(+) B cells was a risk factor for and may predict development of allergic disease at 8 years of age. A high proportion of Tregs was not protective against development of these conditions.High proportions of neonatal naïve B cells remained as a risk factor for allergic disease in school-aged children. Thus, the accelerated B-cell maturation observed among farmers' children may be crucial for the allergy-protective effect of a farming environment. This article is protected by copyright. All rights reserved.

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