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CSF YKL-40 and GAP-43 are related to suicidal ideation in older women

Journal article
Authors Irma Rymo
Silke Kern
Maria Bjerke
Henrik Zetterberg
Thomas Marlow
Kaj Blennow
Pia Gudmundsson
Ingmar Skoog
Margda Waern
Published in Acta Psychiatrica Scandinavica
Volume 135
Issue 4
Pages 351-357
ISSN 0001-690X
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 351-357
Language en
Links dx.doi.org/10.1111/acps.12701
Keywords Depression, Old-age, Suicide
Subject categories Neurochemistry

Abstract

© 2017 John Wiley & Sons A/S.Objective: To investigate possible relationships between suicidal ideation and cerebrospinal fluid (CSF) levels of glial markers YKL-40 (also known as chitinase-3-like protein 1), growth-associated protein-43 (GAP-43) and myelin basic protein (MBP). Method: The sample was obtained from the Prospective Population Study of Women and included 86 women without dementia who underwent both psychiatric examinations and lumbar puncture (LP). Eight of these women reported past-month suicidal ideation. Results: Significantly, higher CSF levels of both YKL-40 and GAP-43 were detected in women with past-month suicidal ideation. Associations with suicidal ideation remained for both YKL-40 and GAP-43 in regression models adjusted for smoking status, BMI and age. CSF levels of YKL-40, GAP-43 and MBP did not differ by depression status. Higher levels of CSF GAP-43 were associated with feelings of worthlessness; a strong relationship was demonstrated in the fully adjusted model (OR 5.95 CI [1.52-23.20], P = 0.01). Conclusion: Our findings of elevated CSF concentrations of both YKL-40 and GAP-43 in women with suicidal ideation, compared to those without, suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.

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