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Cardiac remodeling and increased central venous pressure underlie elevated stroke volume and cardiac output of seawater-acclimated rainbow trout

Journal article
Authors Jeroen Brijs
Erik Sandblom
Esmée Dekens
Joacim Näslund
Andreas Ekström
Michael Axelsson
Published in American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume 312
Issue 1
Pages R31-R39
ISSN 0363-6119
Publication year 2017
Published at Department of Biological and Environmental Sciences
Pages R31-R39
Language en
Links dx.doi.org/10.1152/ajpregu.00374.20...
Keywords Cardiac filling pressure, Cardiovascular, Circulation, Osmoregulation, Venous capacitance, Venous tone
Subject categories Animal physiology

Abstract

© 2017 the American Physiological Society.Substantial increases in cardiac output (CO), stroke volume (SV), and gastrointestinal blood flow are essential for euryhaline rainbow trout (Oncorhyncus mykiss) osmoregulation in seawater. However, the underlying hemodynamic mechanisms responsible for these changes are unknown. By examining a range of circulatory and cardiac morphological variables of seawater-and freshwater-acclimated rainbow trout, the present study revealed a significantly higher central venous pressure (CVP) in seawater-acclimated trout (~0.09 vs. -0.02 kPa). This serves to increase cardiac end-diastolic volume in seawater and explains the elevations in SV (~0.41 vs. 0.27 ml/kg) and CO (~21.5 vs. 14.2 ml·min-1·kg-1) when compared with trout in freshwater. Furthermore, these hemodynamic modifications coincided with a significant increase in the proportion of compact myocardium, which may be necessary to compensate for the increased wall tension associated with a larger stroke volume. Following a temperature increase from 10 to 16.5°C, both acclimation groups exhibited similar increases in heart rate (Q10 of ~2), but SV tended to decrease in seawater-acclimated trout despite the fact that CVP was maintained in both groups. This resulted in CO of seawaterand freshwater-acclimated trout stabilizing at a similar level after warming (~26 ml·min-1·kg-1). The consistently higher CVP of seawater-acclimated trout suggests that factors other than compromised cardiac filling constrained the SV and CO of these individuals at high temperatures. The present study highlights, for the first time, the complex interacting effects of temperature and water salinity on cardiovascular responses in a euryhaline fish species.

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