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IGF-I in the clinics: Use in retinopathy of prematurity

Journal article
Authors Ann Hellström
D. Ley
I. Hansen-Pupp
B. Hallberg
L. A. Ramenghi
Chatarina Löfqvist
L. E. H. Smith
A. L. Hard
Published in Growth Hormone & Igf Research
Volume 30-31
Pages 75-80
ISSN 1096-6374
Publication year 2016
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 75-80
Language en
Links dx.doi.org/10.1016/j.ghir.2016.09.0...
Keywords Fetus, Preterm infant, Postnatal growth, IGF-1, Metabolism, Preterm morbidity, growth-factor-i, oxygen-induced retinopathy, factor-binding-proteins, vascular endothelial-cells, extremely preterm infants, retinal, neovascularization, saturation targets, human-fetus, glucose-transport, postnatal weight, Cell Biology
Subject categories Clinical Medicine

Abstract

Retinopathy of prematurity is a potentially blinding disease, which is associated with low neonatal IGF-I serum concentrations and poor growth. In severe cases impaired retinal vessel growth is followed by pathologic neovascularization, which may lead to retinal detachment. IGF-I may promote growth even in catabolic states. Treating preterm infants with recombinant human (rh) IGF-I to concentrations normally found during gestation has been suggested to have a preventative effect on ROP. A recent phase 2 study treating infants (gestational age between 23 weeks + 0 days and 27 weeks +6 days) with rhIGF-I/IGF binding protein-3 until 30 postmenstrual weeks showed no effect on ROP but a 53% reduction in severe bronchopulmonary dysplasia and 44% reduction in severe intraventricular hemorrhage. Oxygen is a major risk factor for ROP and during the phase 2 study oxygen saturation targets were increased to 90-95%, due to national guidelines, which might have affected ROP rate and severity making increased IGF-I a weaker preventative factor for ROP.

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