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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.

Journal article
Authors Anu Pasanen
Minna K Karjalainen
Louis Bont
Eija Piippo-Savolainen
Marja Ruotsalainen
Emma Goksör
Kuldeep Kumawat
Hennie Hodemaekers
Kirsi Nuolivirta
Tuomas Jartti
Göran Wennergren
Mikko Hallman
Mika Rämet
Matti Korppi
Published in Scientific reports
Volume 7
ISSN 2045-2322
Publication year 2017
Published at Institute of Clinical Sciences, Department of Pediatrics
Language en
Links dx.doi.org/10.1038/srep41653
www.ncbi.nlm.nih.gov/entrez/query.f...
https://gup.ub.gu.se/file/206880
Subject categories Pediatrics

Abstract

Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish-Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (n = 77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (p < 10(-5)) were observed in the GWAS. In the replication population, three SNPs were nominally associated (p < 0.05). Of them, rs269094 was an expression quantitative trait locus (eQTL) for KCND3, previously shown to be associated with occupational asthma. In the additional set of Finnish cases, the association for another SNP (rs9591920) within a noncoding RNA locus was further strengthened. Our results provide a first genome-wide examination of the genetics underlying bronchiolitis. These preliminary findings require further validation in a larger sample size.

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