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Plants salvage deoxyribonucleosides in mitochondria

Journal article
Authors Anders R Clausen
Z. Mutahir
B. Munch-Petersen
J. Piskur
Published in Nucleosides, Nucleotides & Nucleic Acids
Volume 33
Issue 4-6
Pages 291-5
ISSN 1525-7770
Publication year 2014
Published at
Pages 291-5
Language en
Links dx.doi.org/10.1080/15257770.2013.85...
Keywords Arabidopsis/cytology/enzymology/metabolism, DNA, Plant/metabolism, Deoxyribonucleosides/*metabolism, Intracellular Space/enzymology, Mitochondria/enzymology/*metabolism, Phosphotransferases (Alcohol Group Acceptor)/metabolism, Protein Transport, Solanum tuberosum/cytology/enzymology/metabolism, Thymidine Kinase/metabolism, Arabidopsis thaliana, deoxyribonucleosides, nucleic acid precursors, phosphorylation, subcellular localization
Subject categories Biochemistry and Molecular Biology

Abstract

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals.

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