To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Deoxyribonucleoside kinas… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Deoxyribonucleoside kinases in two aquatic bacteria with high specificity for thymidine and deoxyadenosine

Journal article
Authors T. Tinta
L. S. Christiansen
A. Konrad
D. A. Liberles
V. Turk
B. Munch-Petersen
J. Piskur
Anders R Clausen
Published in FEMS Microbiol Lett
Volume 331
Issue 2
Pages 120-7
ISSN 0378-1097
Publication year 2012
Published at
Pages 120-7
Language en
Keywords Computational Biology/methods, Deoxyadenosines/*metabolism, Flavobacteriaceae/*enzymology/genetics, Flavobacterium/*enzymology/genetics, Genome, Bacterial, Kinetics, Phosphotransferases (Alcohol Group Acceptor)/*genetics/*metabolism, Phylogeny, Recombinant Proteins/genetics/metabolism, Substrate Specificity, Thymidine/*metabolism, Thymidine Kinase/genetics/metabolism, *Water Microbiology
Subject categories Biochemistry and Molecular Biology


Deoxyribonucleoside kinases (dNKs) are essential in the mammalian cell but their 'importance' in bacteria, especially aquatic ones, is less clear. We studied two aquatic bacteria, Gram-negative Flavobacterium psychrophilum JIP02/86 and Polaribacter sp. MED152, for their ability to salvage deoxyribonucleosides (dNs). Both had a Gram-positive-type thymidine kinase (TK1), which could phosphorylate thymidine, and one non-TK1 dNK, which could efficiently phosphorylate deoxyadenosine and slightly also deoxycytosine. Surprisingly, the four tested dNKs could not phosphorylate deoxyguanosine, and apparently, these two bacteria are missing this activity. When tens of available aquatic bacteria genomes were examined for the presence of dNKs, a majority had at least a TK1-like gene, but several lacked any dNKs. Apparently, among aquatic bacteria, the role of the dN salvage varies.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?