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Fluoride content in breast milk after the use of fluoridated food supplement. A randomized clinical trial.

Journal article
Authors Guglielmo Campus
Giovanna Congiu
Fabio Cocco
Silvana Sale
Maria Grazia Cagetti
Gavino Sanna
Peter Lingström
Franklin Garcia-Godoy
Published in American Journal of Dentistry
Volume 27
Issue 4
Pages 199-202
ISSN 0894-8275
Publication year 2014
Published at Institute of Odontology, Section 3
Pages 199-202
Language en
Keywords Dietary Supplements, Double-Blind Method, Female, Fluorides, administration & dosage, analysis, Humans, Milk, Human, chemistry, Placebos
Subject categories Dentistry


To evaluate if the intake of a fluoridated food supplement in breastfeeding mothers increases the fluoride concentration in breast milk.A double-blind randomized placebo-controlled study was designed. Two groups of women were formed: a fluoride group (n = 112), using a non-sucrose food supplement containing fluoride (1,500 μg/l for each dose) and a control group (n = 116), using a non-sucrose food supplement without fluoride content. The women were followed for 6 weeks. Samples of breast milk were collected and analyzed using an ion-specific electrode.85 women in the fluoride group and 83 in the control group concluded the trial. Fluoride concentrations in the two groups were statistically significantly different (515 μg/l in the fluoride and 476 μg/l in the control group P= 0.04) at the end of the experimental period. In the fluoride group, a statistically significant increment in fluoride concentration during the experimental period was also observed (from 468 ± 104 μg/l to 515 ± 105 μg/l). The use of a non-sucrose food supplement containing fluoride resulted in a significant increment in fluoride concentration in breast milk.

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