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Live donors of the initial observational study of uterus transplantation-Psychological and medical follow up until 1 year after surgery in the 9 cases.

Journal article
Authors Niclas Kvarnström
Stina Järvholm
Liza Johannesson
Pernilla Dahm-Kähler
Michael Olausson
Mats Brännström
Published in Transplantation
Volume 101
Issue 3
Pages 664-670
ISSN 1534-6080
Publication year 2017
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 664-670
Language en
Links dx.doi.org/10.1097/TP.0000000000001...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Obstetrics, Gynecology and Reproductive Medicine

Abstract

The first prospective observational study of uterus transplantation was initiated in 2013 with live donation to 9 women with absolute uterine factor infertility. We explored the medical complications and psychosocial wellbeing of the donors during the first postoperative year.Complications were registered and graded according to the Clavien-Dindo (C-D) classification. Symptoms related to the surgery were registered. Data on length of hospital stay, sick leave, socioeconomic parameters and life events were obtained. Psychological evaluations (PGWB, DAS, HADS, SF-36) questionnaires focusing on quality-of-life, mood, and relationship, were conducted at inclusion and at 3, 6 and 12 months after uterus donation.One major surgical complication (C-D IIIb) occurred. A ureteric-vaginal fistula developed 2 weeks after uterus procurement. The fistula was surgically repaired. Two self-reported and transient complications (C-D I) were noted (nocturia, meralgia paresthetica). Hospital stays of all donors were 6 days and median sick leave was 56 days (range 14-132). At inclusion, median scores exceeded the normative values of the Swedish population in PGWB and DAS. Anxiety (HADS-A) was detected preoperatively in 1 donor. Two donors exceeded 10-point declines in SF-36 summary scores and increased their HADS scores by 6 points during the observation period. All donors returned to their predonation levels of physical health.The results support that it is feasible to retrieve a uterus safely from a live donor. Further studies are needed to better evaluate the method.

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