To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

TLX-Its Emerging Role for… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

TLX-Its Emerging Role for Neurogenesis in Health and Disease

Review article
Authors Praveen Sobhan
Keiko Funa
Published in Molecular Neurobiology
Volume 54
Issue 1
Pages 272–280
ISSN 0893-7648
Publication year 2017
Published at Sahlgrenska Cancer Center
Institute of Biomedicine
Pages 272–280
Language en
Keywords Glioma; NR2E1; Nervous system tumours; Neural stem cells; Neuroblastoma; Neuropsychiatric disorders; Review; TLX
Subject categories Basic Medicine


The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription factor, TLX is vital for the expression of genes implicated in neurogenesis, such as DNA replication, cell cycle, adhesion and migration. It acts by way of repressing or activating target genes, as well as controlling protein-protein interactions. Growing evidence suggests that dysregulated TLX acts in the initiation and progression of human disorders of the nervous system. This review describes recent knowledge about TLX expression, structure, targets, and biological functions, relevant to maintaining adult neural stem cells related to both neuropsychiatric conditions and certain nervous system tumours.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?