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TLX-Its Emerging Role for Neurogenesis in Health and Disease

Review article
Authors Praveen Sobhan
Keiko Funa
Published in Molecular Neurobiology
Volume 54
Issue 1
Pages 272–280
ISSN 0893-7648
Publication year 2017
Published at Sahlgrenska Cancer Center
Institute of Biomedicine
Pages 272–280
Language en
Links dx.doi.org/10.1007/s12035-015-9608-...
Keywords Glioma; NR2E1; Nervous system tumours; Neural stem cells; Neuroblastoma; Neuropsychiatric disorders; Review; TLX
Subject categories Basic Medicine

Abstract

The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription factor, TLX is vital for the expression of genes implicated in neurogenesis, such as DNA replication, cell cycle, adhesion and migration. It acts by way of repressing or activating target genes, as well as controlling protein-protein interactions. Growing evidence suggests that dysregulated TLX acts in the initiation and progression of human disorders of the nervous system. This review describes recent knowledge about TLX expression, structure, targets, and biological functions, relevant to maintaining adult neural stem cells related to both neuropsychiatric conditions and certain nervous system tumours.

Page Manager: Webmaster|Last update: 9/11/2012
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