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Incidental Findings and Their Handling in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Chapter in book
Authors Åse (Allansdotter) Johnsson
Oskar Angerås
Anders Blomberg
David Erlinge
Agneta Flinck
Christer Janson
Hanna Markstad
Jonas Persson
Eva Swahn
Kjell Torén
Jenny Vikgren
Mats G. Hansson
Göran Bergström
Published in Incidental Radiological Findings. (Series: Medical Radiology)
Pages 91-101
ISBN 978-3-319-42581-8
ISSN 0942-5373
Publisher Springer
Publication year 2016
Published at Wallenberg Laboratory
Institute of Medicine, School of Public Health and Community Medicine
Institute of Clinical Sciences, Department of Radiology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 91-101
Language en
Keywords Epidemiology, Cardiovascular, Pulmonary, Metabolism, Study design
Subject categories Clinical Medicine


The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS is currently recruiting at six sites in Sweden, and a pilot study was conducted in 2012 to test the feasibility of the comprehensive study protocol. In the planning phase, it was recognized that the detailed phenotyping used in SCAPIS would identify a large number of clinical findings in need of medical attention. This was confirmed by evaluation of results from the pilot study. Here we focus on pulmonary nodules and asymptomatic coronary artery stenosis. These clinical features were observed in a large number of participants, and the clinical handing and prognosis related to these observations are unclear. They thus posed great challenges for the study in their practical and ethical handling. This chapter describes how we developed procedures to handle these findings based on existing evidence and expert consensus as well as deliberations on ethical issues.

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