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ABO antigen expression in graft tissue: is titration against donor erythrocytes relevant?

Journal article
Authors L Rydberg
Ulrika Skogsberg
Johan Mölne
Published in Transplantation
Volume 84
Issue 12 Suppl
Pages S10-2
ISSN 0041-1337
Publication year 2007
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Biomedicine, Department of Pathology
Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Pages S10-2
Language en
Links dx.doi.org/10.1097/01.tp.0000296017...
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords ABO Blood-Group System, Blood Group Incompatibility, Erythrocytes, immunology, Humans, Immunoglobulin A, chemistry, Immunoglobulin G, chemistry, Immunosuppressive Agents, therapeutic use, Kidney, immunology, Kidney Transplantation, immunology, methods, Liver Transplantation, immunology, methods, Male, Middle Aged, Time Factors, Treatment Outcome
Subject categories Clinical Laboratory Medicine

Abstract

ABO-incompatible living donor renal transplantation has become an accepted treatment for end-stage renal disease. Two main factors appear to be important when crossing the ABO barrier, the donor organ A/B antigen expression and the amount of recipient anti-A/B antibody. Antigen expression depends on the ABO blood group and subgroup and may vary in different tissues and cells. The amount of recipient anti-A/B antibody, determined by titration, is very variable. One major drawback with titration is the lack of conformity between different laboratories, making comparisons difficult. For clinical use, the anti-A/B antibody titration technique has to be simple, rapid, and cheap, in addition to being accurate. Although there is a need for more standardized procedures for determination of ABO antibodies, existing techniques are sufficient in the clinical care of patients. To illustrate the variation in susceptibility of different graft tissues to ABO antibodies, in this paper we describe a case of an ABO-incompatible combined liver and kidney transplantation.

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