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Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors - potential crosstalk of cholinergic mechanisms during pharmacological treatment.

Journal article
Authors Ondrej Soukup
Michael Winder
Uday Kumar Killi
Vladimir Wsol
Daniel Jun
Kamil Kuca
Gunnar Tobin
Published in Current neuropharmacology
Volume 15
Issue 4
Pages 637-653
ISSN 1875-6190
Publication year 2017
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 637-653
Language en
Links dx.doi.org/10.2174/1570159X14666160...
Subject categories Pharmacology

Abstract

Pharmaceuticals with targets in the cholinergic transmission have been used for decades and are still fundamental treatments in many diseases and conditions today. Both the transmission and the effects of the somatomotoric and the parasympathetic nervous systems may be targeted by such treatments. Irrespective of the knowledge that the effects of neuronal signalling in the nervous systems may include a number of different receptor subtypes of both the nicotinic and the muscarinic receptors, this complexity is generally overlooked when assessing the mechanisms of action of pharmaceuticals. Presently, the life cycle of acetylcholine, muscarinic receptors and their effects are reviewed in the major organ systems of the body. Neuronal and non-neuronal sources of acetylcholine are elucidated. Examples of pharmaceuticals, in particular cholinesterase inhibitors, affecting these systems are discussed. The review focuses on salivary glands, the respiratory tract and the lower urinary tract, since the complexity of the interplay of different muscarinic receptor subtypes is of significance for physiological, pharmacological and toxicological effects in these organs.

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