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Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.

Journal article
Authors Jeymohan Joseph
Paola Cinque
Deborah Colosi
Ameet Dravid
Luminita Ene
Howard Fox
Dana Gabuzda
Magnus Gisslén
Sarah Beth Joseph
Scott Letendre
Shibani S Mukerji
Avindra Nath
Ignacio Perez-Valero
Deborah Persaud
Richard W Price
Vasudev R Rao
Ned Sacktor
Ronald Swanstrom
Alan Winston
Valerie Wojna
Edwina Wright
Serena Spudich
Published in Journal of virus eradication
Volume 2
Issue 4
Pages 243-250
ISSN 2055-6640
Publication year 2016
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 243-250
Language en
Links https://www.ncbi.nlm.nih.gov/pmc/ar...
Subject categories Infectious Medicine

Abstract

CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.

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