To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Serum neurofilament light… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

Journal article
Authors Pashtun Shahim
Magnus Gren
Victor Liman
Ulf Andreasson
N. Norgren
Y. Tegner
N. Mattsson
N. Andreasen
Martin Öst
Henrik Zetterberg
Bengt Nellgård
Kaj Blennow
Published in Scientific Reports
Volume 6
ISSN 2045-2322
Publication year 2016
Published at Institute of Neuroscience and Physiology
Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Language en
Links dx.doi.org/10.1038/srep36791
Keywords cerebrospinal-fluid, multiple-sclerosis, s-100b protein, s100b, biomarkers, disease, damage, severity, players, blood, Science & Technology - Other Topics
Subject categories Neuroscience

Abstract

Axonal white matter injury is believed to be a major determinant of adverse outcomes following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament light protein (NF-L), a protein found in long white-matter axons, in blood samples, may serve as a suitable biomarker for neuronal damage in TBI patients. To test our hypotheses, we designed a study in two parts: i) we developed an immunoassay based on Single molecule array technology for quantification of NF-L in blood, and ii) in a proof-of-concept study, we tested our newly developed method on serial serum samples from severe TBI (sTBI) patients (n = 72) and controls (n = 35). We also compared the diagnostic and prognostic utility of NF-L with the established blood biomarker S100B. NF-L levels were markedly increased in sTBI patients compared with controls. NF-L at admission yielded an AUC of 0.99 to detect TBI versus controls (AUC 0.96 for S100B), and increased to 1.00 at day 12 (0.65 for S100B). Importantly, initial NF-L levels predicted poor 12-month clinical outcome. In contrast, S100B was not related to outcome. Taken together, our data suggests that measurement of serum NF-L may be useful to assess the severity of neuronal injury following sTBI.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?