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Immunohistochemical biomarkers in ameloblastomas

Journal article
Authors A. M. do Canto
J. R. Rozatto
J. L. Schussel
R. R. de Freitas
Bengt Hasséus
P. H. Braz-Silva
Published in Acta Odontologica Scandinavica
Volume 74
Issue 8
Pages 585-590
ISSN 0001-6357
Publication year 2016
Published at Institute of Odontology
Pages 585-590
Language en
Keywords Ameloblastoma, immunohistochemistry, jaw, odontogenic tumours, keratocystic odontogenic-tumor, kappa-b ligand, differential expression, cell-proliferation, mutations, osteoclastogenesis, pathogenesis, population, frequency, activator, Dentistry, Oral Surgery & Medicine
Subject categories Dentistry


Ameloblastoma is an aggressive odontogenic tumour, which is locally invasive and highly recurrent. Studies show that ameloblastoma is a benign odontogenic neoplasia, being relatively rare and occasionally presenting behaviour of malignant lesions. In addition to these particularities, the histological diagnosis of ameloblastoma can be challenging when the tumour shows high rates of mitosis, absence of nuclear pleomorphism, basilar hyperplasia and neural invasion. In order to help in the diagnosis, prognosis and treatment of this neoplasia, some immunohistochemical markers were shown to be associated with tumoural epithelium. The identification of these markers as well as of their association with clinical signs can be useful to elaborate more efficient treatment strategies and to control this pathology, including improvement of the quality of life of patients affected by this neoplasia. This article aims to review some markers associated with specific molecular pathways, bone remodelling, cell proliferation, apoptosis, cell signalling and tumour suppression.

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